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                               May 16, 2023

       Derek Zaba, Esq.
       Partner
       Sidley Austin LLP
       787 Seventh Avenue
       New York, New York 10019

                                                        Re: Alkermes plc.
                                                            PREC14A filed May
8, 2023
                                                            File No. 1-35299

       Dear Derek Zaba:

              We have reviewed your filing and have the following comments. In
some of our
       comments, we may ask you to provide us with information so we may better
understand your
       disclosure.

               Please respond to these comments by providing the requested
information or advise us as
       soon as possible when you will respond. If you do not believe our
comments apply to your facts
       and circumstances, please tell us why in your response.

               After reviewing your response to these comments, we may have
additional comments.
       All defined terms have the same meaning as in the proxy statement listed
above.

       PREC14A filed May 8, 2023

       General Information about the Meeting and Voting

   1.                                                   At the bottom of page
17, you disclose that if a proxy card is returned that specifies a vote
                                                        on some but not all
matters presented on the card, the proxy will be voted on the matters
                                                        left blank in the
manner recommended by the board and specified in the registrant's proxy
                                                        statement. However, the
form of proxy addresses only how you will vote a signed but
                                                        completely unmarked
card. Please revise or advise.
       Proposal 1 - Election of Directors

   2.                                                   Rule 14a-4(b)(i)
requires you to include a "WITHHOLD" option where the voting
                                                        standard for election
of directors is a plurality and where an "AGAINST" vote has no
                                                        legal effect. Here, you
have included an "AGAINST" voting option despite the fact that
                                                        your disclosure
indicates it will have no legal effect. We note that Irish law requires such
                                                        an option but U.S.
rules prohibit it. See Rule 14a-4(b). Please revise or advise.
 Derek Zaba, Esq.
Sidley Austin LLP
May 16, 2023
Page 2
3.       See our last comment above. Rule 14a-4(b)(i) requires you to include a
"WITHHOLD"
         option in an election contest with a plurality voting option. You have
included an
         "ABSTAIN" option instead. Please revise or advise.
4.       Here or where appropriate in the proxy statement, include a statement
directing
         shareholders to Sarissa's proxy statement for the information required
by Item 7
         of Schedule 14A with respect to its nominees. This statement should
note that
         shareholders can access Sarissa's proxy statement, and any other
relevant documents,
         without cost on the Commission's website.
5.       Disclose what you will do with votes for Sarissa's nominees received
on your proxy
         card if Sarissa discontinues its solicitation or fails to solicit the
holders of at least 67% of
         the voting power of these common shares. See Item 21(c) of Regulation
14A.
Form of Proxy

6.       We note that your proxy card provides for the ability to vote by
telephone. It is our
         understanding that certain voting platforms do not permit telephonic
voting for contests
         involving a universal proxy card. Please revise or advise. Should you
delete the
         references to voting by telephone on the proxy card, please make
corresponding changes
         to the disclosure in the proxy statement itself, such as on page 4 and
elsewhere.
        We remind you that the filing persons are responsible for the accuracy
and adequacy of
their disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

         Please direct any questions to Christina Chalk at (202) 551-3263.



FirstName LastNameDerek Zaba, Esq.                                Sincerely,
Comapany NameSidley Austin LLP
                                                                  Division of
Corporation Finance
May 16, 2023 Page 2                                               Office of
Mergers & Acquisitions
FirstName LastName