Press Releases


Alkermes Announces First Quarter Fiscal 2007 Results

-- Total Revenues More than Doubled Compared to First Quarter Fiscal 2006 --

CAMBRIDGE, Mass., Aug 08, 2006 (BUSINESS WIRE) --Alkermes, Inc. (Nasdaq: ALKS) today announced financial results for the first quarter of fiscal 2007. Highlights for the quarter ended June 30, 2006 include:

  • Total revenues of $51.5 million, a 107 percent increase over total revenues of $24.8 million for the same period in 2005.
  • Net loss on a GAAP basis of $0.7 million compared to a net loss of $13.7 million for the same period in 2005.
  • Strong cash position and total investments of $373.7 million following receipt of the $110 million milestone from Cephalon, Inc. (Cephalon) upon approval by the U.S. Food and Drug Administration (FDA) of VIVITROL(R).

As a result of the adoption of Statement of Financial Accounting Standards No. 123R (Share-Based Payment), on April 1, 2006, Alkermes is reporting share-based compensation expense in its GAAP results.

  • GAAP net loss for the first quarter ended June 30, 2006 was $0.7 million or a basic and diluted loss per share of $0.01, including $8.3 million in share-based compensation expense, as compared to a net loss of $13.7 million or a basic and diluted loss per share of $0.15 for the same period in 2005.
  • Non-GAAP net income for the first quarter ended June 30, 2006 was $6.8 million or a basic and diluted earnings per share of $0.07, compared to a net loss of $13.8 million or basic and diluted loss per share of $0.15 for the same period in 2005.

Alkermes is providing non-GAAP results as a complement to GAAP results. The non-GAAP net income excludes certain noncash or nonrecurring items, and Alkermes' management believes these pro forma measures help to indicate underlying trends in the Company's ongoing operations. The reconciliation between non-GAAP and GAAP earnings per share for the first quarters of fiscal 2007 and 2006 is provided in the following table:

                                                     Net
                                                Increase      Reported
               Non-GAAP Diluted  Share-Based     in Fair          GAAP
                Earnings (Loss) Compensation    Value of  Diluted Loss
                      per Share   Expense(1)    Warrants     per Share
----------------------------------------------------------------------
Q1 FY 2007               $0.07       ($0.08)       $0.01       ($0.01)
----------------------------------------------------------------------
Q1 FY  2006             ($0.15)          --           --       ($0.15)
----------------------------------------------------------------------

Note: Amounts may not sum due to rounding.

"We are pleased with the progress we made in our business during the first fiscal quarter, specifically with our strong revenue growth. We also achieved important product milestones, including the launch of VIVITROL and the completion of enrollment in a key registration study for AIR Inhaled Insulin," stated James Frates, chief financial officer of Alkermes. "We continue to focus on our commercial, clinical and corporate objectives, including supplying RISPERDAL CONSTA and VIVITROL, advancing our product pipeline, and achieving sustained operating profitability."

Revenues

  • Total revenues for the quarter ended June 30, 2006, were $51.5 million, compared to $24.8 million for the same period in 2005.
  • Total manufacturing revenues for the quarter ended June 30, 2006 were $22.2 million, comprised of $19.1 million for RISPERDAL(R) CONSTA(R) and $3.1 million for VIVITROL, compared to $14.0 million for the same period in 2005, all of which related to RISPERDAL CONSTA.
  • Royalty revenues for the quarter ended June 30, 2006 were $5.1 million based on RISPERDAL CONSTA sales of $205 million, compared to $3.6 million based on RISPERDAL CONSTA sales of $144 million for the same period in 2005.
  • Research and development revenue under collaborative arrangements for the quarter ended June 30, 2006 was $14.5 million, compared to $7.3 million for the same period in 2005.
  • Net collaborative profit for the quarter ended June 30, 2006 was $9.7 million. The Company did not recognize any net collaborative profit for the same period in 2005.

Costs and Expenses

  • Cost of goods manufactured, on a non-GAAP basis, for the quarter ended June 30, 2006 was $9.0 million, of which $6.3 million related to RISPERDAL CONSTA and $2.7 million related to VIVITROL, compared to $4.5 million for the same period in 2005, all of which related to RISPERDAL CONSTA. On a GAAP basis, cost of goods manufactured for the quarter ended June 30, 2006 was $9.3 million, including share-based compensation expense of $0.3 million.
  • Research and development (R&D) expenses, on a non-GAAP basis, for the quarter ended June 30, 2006 were $23.1 million, compared to $21.6 million for the same period in 2005. On a GAAP basis, R&D expenses for the quarter ended June 30, 2006 were $25.9 million, including share-based compensation expense of $2.8 million.
  • Selling, general and administrative (SG&A) expenses, on a non-GAAP basis, for the quarter ended June 30, 2006 were $11.3 million, compared to $9.0 million for the same period in 2005. On a GAAP basis, SG&A expenses for the quarter ended June 30, 2006 were $16.5 million, including share-based compensation expense of $5.2 million.
  • Interest income for the quarter ended June 30, 2006 was $4.3 million compared to $1.6 million for the same period in 2005. Interest expense was $5.5 million for the quarter ended June 30, 2006 compared to $5.2 million for the same period in 2005.

At June 30, 2006, Alkermes had cash and total investments of $373.7 million, compared to $303.1 million at March 31, 2006. This includes the receipt of the $110 million milestone payment from Cephalon following the FDA approval of VIVITROL in April 2006.

Recent Highlights

  • VIVITROL: Alkermes and Cephalon launched VIVITROL in the United States on June 13, 2006.
  • AIR(R) Inhaled Insulin: Alkermes and Eli Lilly and Company (Eli Lilly) announced results from studies of AIR Inhaled Insulin (AIR Insulin) presented at the 66th Annual Scientific Sessions of the American Diabetes Association (ADA), including results from a Phase II study comparing two levels of training intensity, and results from a Phase I study in subjects with chronic obstructive pulmonary disease (COPD). The companies also announced the completion of enrollment of a Phase III, two-year safety and efficacy study for AIR Insulin.
  • Exenatide LAR: Amylin Pharmaceuticals, Inc., Eli Lilly, and Alkermes announced detailed results from a Phase II, 45-patient safety and efficacy study of exenatide LAR presented at the 66th Annual Scientific Sessions of the ADA, demonstrating that 86 percent of patients using the higher of two doses of exenatide LAR were able to achieve recommended levels of glucose control, as measured by hemoglobin A1C, with an average improvement of approximately two percent compared to placebo.

Conference Call

Alkermes will host a conference call at 4:30 p.m. EDT on Tuesday, August 8, 2006 to discuss these financial results and provide an update on the Company. The conference call may be accessed by dialing 1-866-818-1223 for domestic callers and 1-703-639-1376 for international callers. The conference call ID number is 943375. In addition, the call will be webcast on the investor relations section of Alkermes' website at www.alkermes.com and archived on the site until Sunday, August 13, 2006 at 5:00 p.m. EDT. Alkermes is also providing a podcast MP3 file available for download on the Alkermes website which will be available shortly following the conference call. A replay of the conference call will be available from 7:30 p.m. EDT on Tuesday, August 8, 2006 through 5:00 p.m. EDT on Sunday, August 13, 2006, and may be accessed by dialing 1-888-266-2081 for domestic callers and 1-703-925-2533 for international callers. The replay access code is 943375.

About Alkermes

Alkermes, Inc. is a biotechnology company that develops products based on sophisticated drug delivery technologies to enhance therapeutic outcomes in major diseases. The Company has two commercial products. RISPERDAL(R) CONSTA(R) ((risperidone) long-acting injection), the first and only long-acting atypical antipsychotic medication approved for use in schizophrenia, is marketed worldwide by Janssen-Cilag (Janssen), a wholly owned division of Johnson & Johnson. VIVITROL(R) (naltrexone for extended-release injectable suspension) is the first and only once-monthly injectable medication approved for the treatment of alcohol dependence and is marketed in the United States primarily by Cephalon, Inc. The Company has a pipeline of extended-release injectable products and pulmonary products based on its proprietary technology and expertise. Alkermes' product development strategy is twofold: the Company partners its proprietary technology systems and drug delivery expertise with several of the world's finest pharmaceutical companies; and it also develops novel, proprietary drug candidates for its own account. The Company's headquarters are in Cambridge, Massachusetts, and it operates research and manufacturing facilities in Massachusetts and Ohio.

Certain statements set forth above may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the therapeutic value of its product candidates to patients; plans for clinical trials; the successful commercialization of VIVITROL; the successful supply of RISPERDAL CONSTA and VIVITROL; and the successful continuation of development activities for its partnered programs. Although the Company believes that such statements are based on reasonable assumptions within the bounds of its knowledge of its business and operations, the forward-looking statements are neither promises nor guarantees and the Company's business is subject to significant risk and uncertainties and there can be no assurance that its actual results will not differ materially from its expectations. These risks and uncertainties include, among others: whether the Company can continue to successfully manufacture RISPERDAL CONSTA and VIVITROL at a commercial scale or economically or in sufficient quantities to supply the market; whether RISPERDAL CONSTA will continue to be commercialized successfully by its partner Janssen and whether VIVITROL will be commercialized successfully by Alkermes and its partner, Cephalon; whether the Company is able to successfully and efficiently scale up and manufacture its product candidates; whether advancement of the Company's partnered product candidates will be delayed due to actions or decisions by its partners with regard to development and regulatory strategy, timing and funding which are out of its control, and the outcome of clinical and preclinical work the Company and its partners are pursuing; decisions by the FDA or foreign regulatory authorities regarding the Company's product candidates; potential changes in cost, scope and duration of clinical trials; and whether RISPERDAL CONSTA, VIVITROL and the Company's product candidates, in commercial use, have unintended side effects, adverse reactions or incidents of misuse that could cause the FDA or other health authorities to require post approval studies or require removal of its products from the market. For further information with respect to factors that could cause the Company's actual results to differ materially from expectations, reference is made to the reports the Company filed with the Securities and Exchange Commission under the Securities Exchange Act of 1934, as amended. The forward-looking statements made in this release are made only as of the date hereof and the Company disclaims any intention or responsibility for updating predictions or financial expectations contained in this release.

AIR(R) is a registered trademark of Alkermes, Inc.; VIVITROL(R) is a registered trademark of Cephalon, Inc.; RISPERDAL(R) CONSTA(R) is a registered trademark of Johnson & Johnson Corporation.

(1) Alkermes, Inc. adopted SFAS No. 123R based on the modified prospective transition method beginning April 1, 2006, and, therefore, no share-based compensation expense was recognized in GAAP-reported results in any prior reporting period under this standard. Based on the Company's pro forma disclosure under SFAS No.148 (Accounting for Stock-Based Compensation--Transition and Disclosure) for reporting periods prior to April 1, 2006 (as previously disclosed in the Company's financial statement footnotes), pro forma share-based compensation expense in the first quarter of fiscal 2006 was $5.8 million, or $0.07 per basic and diluted share, and the resulting non-GAAP loss per basic and diluted share was $0.22.


                  Alkermes, Inc. and Subsidiaries
             Selected Financial Information (Unaudited)


                                                     Three    Three
                                                      Months   Months
                                                     Ended     Ended
Condensed Consolidated Statements of Operations     June 30, June 30,
(In thousands, except per share data)                  2006      2005
----------------------------------------------------------------------
Revenues:
  Manufacturing revenues                            $22,193   $13,983
  Royalty revenues                                    5,139     3,604
  Research and development revenue under
   collaborative arrangements                        14,464     7,251
  Net collaborative profit                            9,742         -
----------------------------------------------------------------------
    Total Revenues                                   51,538    24,838
----------------------------------------------------------------------
Expenses:
  Cost of goods manufactured                          9,338     4,517
  Research and development                           25,863    21,622
  Selling, general and administrative                16,530     8,952
----------------------------------------------------------------------
    Total Expenses                                   51,731    35,091
----------------------------------------------------------------------
Operating Loss                                         (193)  (10,253)
----------------------------------------------------------------------
Other Income (Expense):
  Interest income                                     4,335     1,631
  Other income (expense), net                           787       320
  Derivative loss related to convertible
   subordinated notes                                     -      (266)
  Interest expense                                   (5,473)   (5,169)
----------------------------------------------------------------------
    Total Other Income (Expense)                       (351)   (3,484)
----------------------------------------------------------------------
Loss before income taxes                               (544)  (13,737)
Income taxes                                            171         -
----------------------------------------------------------------------
Net Loss                                              ($715) ($13,737)
======================================================================

Loss per Common Share (GAAP):
  Basic and Diluted                                  ($0.01)   ($0.15)
----------------------------------------------------------------------

Weighted Average Number of Common Shares Outstanding (GAAP):
  Basic and Diluted                                  93,784    90,410
----------------------------------------------------------------------

Pro Forma Reconciliation:
Net Loss - GAAP                                       ($715) ($13,737)
  Share-based compensation expense                    8,347         -
  Net increase in the fair value of warrants           (846)     (308)
  Derivative loss related to convertible
   subordinated notes                                     -       266
----------------------------------------------------------------------
Net Income (Loss) - non-GAAP                         $6,786  ($13,779)
----------------------------------------------------------------------

Earnings (Loss) per Common Share (non-GAAP):
  Basic                                               $0.07    ($0.15)
----------------------------------------------------------------------
  Diluted                                             $0.07    ($0.15)
----------------------------------------------------------------------

Weighted Average Number of Common Shares Outstanding (non-GAAP):
  Basic                                              93,784    90,410
----------------------------------------------------------------------
  Diluted                                            99,754    90,410
----------------------------------------------------------------------



Condensed Consolidated Balance Sheets               June 30, March 31,
(In thousands)                                         2006      2006
----------------------------------------------------------------------
Cash, cash equivalents and total investments       $373,684  $303,112
Receivables, prepaid expenses and other current
 assets                                              46,155    42,584
Inventory                                            11,378     7,341
Property, plant and equipment, net                  116,246   112,917
Other assets                                         10,290    11,209
----------------------------------------------------------------------
Total Assets                                       $557,753  $477,163
----------------------------------------------------------------------
Unearned milestone revenue - current portion        $56,320   $83,338
Other current liabilities                            34,947    42,322
Unearned milestone revenue - long-term portion      124,319    16,198
Non-recourse Risperdal Consta secured 7% notes      154,427   153,653
Other long-term debt                                  1,200   125,865
Other long-term liabilities                           7,377     7,571
Redeemable convertible preferred stock               15,000    15,000
Total shareholders' equity                          164,163    33,216
----------------------------------------------------------------------
Total Liabilities, Redeemable Convertible Preferred
 Stock and Shareholders' Equity                    $557,753  $477,163
----------------------------------------------------------------------

This selected financial information should be read in conjunction
with the consolidated financial statements and notes thereto included
in the Company's Annual Report on Form 10-K for the year ended March
31, 2006 and the Company's report on Form 10-Q for the three months
ended June 30, 2006.


Net Collaborative Profit - VIVITROL(R)
 Collaboration                                   Three
                                                 Months
------------------------------------------------ Ended    Cumulative
                                                June 30, Collaboration
   (Unaudited, in thousands)                       2006     To-Date
                                                -------- -------------

   Milestone revenue recognized to offset
    expenses incurred on VIVITROL:
              Alkermes, Inc. expenses incurred
               on behalf of the collaboration
               (1)                               $8,355       $28,145
              Cephalon, Inc. expenses incurred
               on behalf of the collaboration
               (1)                               18,873        40,052
              Alkermes, Inc. expenses incurred
               outside the collaboration  (2)       196        19,691
                                                -------- -------------
                                                 27,424        87,888

   Milestone revenue recognized with respect to
    license  (3)                                  1,191         1,191

   Flow of funds to Cephalon, Inc.  (4)         (18,873)      (40,052)

                                                -------- -------------
   Net collaborative profit                      $9,742       $49,027
                                                ======== =============



Notes
-----------

(1) Expenses incurred on behalf of the collaboration by Alkermes, Inc.
    ("Alkermes") and net losses incurred on behalf of the
    collaboration by Cephalon, Inc. ("Cephalon") contribute to the
    cumulative net product losses incurred on VIVITROL. Alkermes is
    responsible for the first $120 million of these cumulative net
    product losses. Through June 30, 2006, $68.2 million of cumulative
    net product losses have been incurred.

(2) Alkermes is solely responsible for the successful approval of
    VIVITROL, and the successful completion of the first VIVITROL
    manufacturing line. These expenses do not contribute to the
    cumulative net product losses.

(3) Milestone revenue related to the license commenced upon approval
    of VIVITROL, by the U.S. Food and Drug Administration, on April
    13, 2006.

(4) Alkermes is responsible for the first $120 million of cumulative
    net product losses during the period ending December 31, 2007, and
    consequently reimburses Cephalon for its net losses incurred on
    VIVITROL during this period.


(1) (2) (3) Through June 30, 2006, Alkermes has recognized $89.4
    million of milestone revenue out of the $270.0 million received
    from Cephalon. In addition to (1), (2) and (3) above, this
    recognition includes $0.3 million of milestone revenue related to
    a 10% mark-up on manufacturing revenue, which is reported by
    Alkermes within manufacturing revenues in the condensed
    consolidated statement of operations.


SOURCE: Alkermes

James Frates
Chief Financial Officer
Alkermes, Inc.
(617) 494-0171
    or
Rebecca Peterson
Vice President, Corporate Communications
Alkermes, Inc.
(617) 583-6378