Press Releases


Alkermes Reports Financial Results for Fiscal 2008 and Provides Financial Expectations for Fiscal 2009

-- Company Reports Strong Financial Performance with Record Net Income of $167 million for Fiscal 2008 --

-- Company Expects Increased Revenues from RISPERDAL(R) CONSTA(R) and Positive Cash Flows from Operations in Fiscal 2009 --

CAMBRIDGE, Mass.--(BUSINESS WIRE)--May 22, 2008--Alkermes, Inc. (NASDAQ: ALKS) today reported financial results for its fiscal year ended March 31, 2008. Financial highlights for the year include the following:

  • Record GAAP net income of $167.0 million.
  • Manufacturing and royalty revenues from RISPERDAL(R) CONSTA(R) of $124.6 million. Worldwide sales of RISPERDAL CONSTA by Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. and Janssen-Cilag (Janssen) were approximately $1.2 billion in fiscal 2008, a 27 percent increase over sales of RISPERDAL CONSTA in fiscal 2007.
  • Repurchase of 7.0 million shares of common stock for $93.4 million as part of an ongoing stock repurchase program.
  • Strong financial position, with cash and total investments of $460.4 million.

"We are very proud of our financial results for fiscal 2008. The foundation of our business is strong and enables us to invest in our pipeline while also continuing our stock repurchase program," commented James Frates, chief financial officer of Alkermes. "In fiscal 2009, we will continue to both generate cash and invest in our growing pipeline."

    Key operating results for fiscal 2008 include the following:

  • Net income was $167.0 million or a basic earnings per share of $1.66 and diluted earnings per share of $1.62, including $19.4 million in share-based compensation expense, compared to a net income of $9.4 million or a basic earnings per share of $0.10 and diluted earnings per share of $0.09 for fiscal 2007. Net income for the year included $174.6 million from the sale of the company's stake in Reliant Pharmaceuticals, Inc. and $3.3 million of associated taxes, as well as restructuring and impairment charges of $18.1 million related primarily to the decision by Eli Lilly and Company (Lilly) to terminate the AIR(R) Insulin program.
  • Pro forma net income was $31.8 million or a basic earnings per share of $0.32 and diluted earnings per share of $0.31, compared to a pro forma net income of $37.9 million or a basic earnings per share of $0.38 and diluted earnings per share of $0.37 for fiscal 2007.

Alkermes is providing pro forma results as a complement to reported results. The pro forma net income excludes certain noncash or nonrecurring items, and Alkermes' management believes these pro forma measures help to indicate underlying trends in the company's ongoing operations. The reconciliation between pro forma and reported diluted earnings per share for fiscal 2008 and fiscal 2007 is provided in the following table:

                                                        Net
                    Income                           Change
                      from      Share-              in Fair  Reported
        Pro Forma  Sale of      Based     Restruc-  Value of  Diluted
         Diluted   Stake in  Compensa- turing and   Warrants  Earnings
         Earnings  Reliant,      tion   Impairment      and       per
                    Net of     Expense     Charges    Deriv-     Share
                      Taxes                           ative
                                                    Loss on
                                                       Notes
----------------------------------------------------------------------
FY 2008     $0.31     $1.66    ($0.19)     ($0.18)    $0.01      $1.62
----------------------------------------------------------------------
FY 2007     $0.37        --    ($0.27)         --    ($0.01)     $0.09
----------------------------------------------------------------------

Note: Amounts may not sum due to rounding.

    Revenues

  • Total revenues for fiscal 2008 were $240.7 million, compared to $240.0 million for fiscal 2007.
  • Total manufacturing revenues for fiscal 2008 were $101.7 million, consisting of $95.2 million for RISPERDAL CONSTA and $6.5 million for VIVITROL(R), compared to $105.4 million for fiscal 2007, consisting of $88.6 million for RISPERDAL CONSTA and $16.8 million for VIVITROL.
  • Royalty revenues for fiscal 2008 were $29.5 million based on RISPERDAL CONSTA sales of $1.2 billion, compared to $23.2 million based on RISPERDAL CONSTA sales of $924.2 million for fiscal 2007.
  • Research and development revenue under collaborative arrangements for fiscal 2008 was $89.5 million, compared to $74.5 million for fiscal 2007.
  • Net collaborative profit for fiscal 2008 was $20.0 million, compared to $36.9 million for fiscal 2007. Gross sales of VIVITROL for fiscal 2008 were $18.0 million, compared to $6.5 million for fiscal 2007.

    Costs and Expenses

  • Cost of goods manufactured for fiscal 2008 was $40.7 million, of which $34.8 million related to RISPERDAL CONSTA and $5.9 million related to VIVITROL, compared to $45.2 million for fiscal 2007, of which $29.9 million related to RISPERDAL CONSTA and $15.3 million related to VIVITROL.
  • Research and development (R&D) expenses for fiscal 2008 were $125.3 million, compared to $117.3 million for fiscal 2007.
  • Selling, general and administrative (SG&A) expenses for fiscal 2008 were $59.5 million, compared to $66.4 million for fiscal 2007.
  • Share-based compensation expense (included in the expenses above) for fiscal 2008 was $19.4 million, of which $1.8 million related to cost of goods manufactured, $7.0 million related to R&D expenses and $10.6 million related to SG&A expenses. Share-based compensation expense for fiscal 2007 was $27.7 million, of which $2.7 million related to cost of goods manufactured, $8.6 million related to R&D expenses and $16.4 million related to SG&A expenses.
  • Impairment expense for fiscal 2008 was $11.6 million and was incurred due to Lilly's decision to terminate the AIR Insulin program. The assets included in the impairment charge were dedicated to the AIR Insulin program.
  • Restructuring expenses for fiscal 2008 were $6.4 million, consisting of a charge of $6.9 million related to Lilly's decision to terminate the AIR Insulin program, partially offset by the reversal of $0.5 million related to a previous restructuring accrual.
  • Interest income for fiscal 2008 was $17.8 million, compared to $17.7 million for fiscal 2007. Interest expense for fiscal 2008 was $16.4 million, compared to $17.7 million for fiscal 2007.
  • Income tax expense for fiscal 2008 was $5.9 million, compared to $1.1 million for fiscal 2007.

At March 31, 2008, Alkermes had cash and total investments of $460.4 million, compared to $516.6 million at December 31, 2007 and $356.7 million at March 31, 2007.

    Recent Highlights

  • RISPERDAL CONSTA data presented at the American Psychiatric Association Annual Meeting. Fourteen posters related to RISPERDAL CONSTA were presented at the American Psychiatric Association (APA) 161st Annual Meeting, including data from a 24-month, open-label study in 710 patients showing that the time to relapse was significantly longer for patients treated with RISPERDAL CONSTA (607 days) compared to patients treated with quetiapine (533 days), p(less than)0.0001. Both RISPERDAL CONSTA and quetiapine had generally comparable safety profiles.
  • Supplemental new drug application for RISPERDAL CONSTA submitted to U.S. Food and Drug Administration. Alkermes' partner, Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), submitted a Supplemental New Drug Application (sNDA) for RISPERDAL CONSTA to the U.S. Food and Drug Administration (FDA) seeking approval for adjunctive maintenance treatment to delay the occurrence of mood episodes in patients with frequently relapsing bipolar disorder (FRBD).
  • Accelerated stock repurchase program completed. During the fourth quarter of fiscal 2008, Alkermes concluded the $60 million accelerated stock repurchase program announced in February 2008. Under the program, the company repurchased 4.7 million shares of common stock.
  • New drug application for VIVITROL submitted in Russia. Alkermes' collaborator, Cilag GmbH International, a subsidiary of Johnson & Johnson, submitted a new drug application to the Russian regulatory authorities. In December 2007, the companies signed an agreement to commercialize VIVITROL for the treatment of alcohol dependence in Russia and other countries in the Commonwealth of Independent States.

Financial Expectations for Fiscal 2009

The following outlines Alkermes' financial expectations for the fiscal year ending March 31, 2009. These financial expectations include the impact of share-based compensation expense. Certain statements set forth below constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. For information with respect to factors that could cause Alkermes' actual results to differ materially from its expectations, please see the risk factors provided at the end of this press release.

  • Revenues: The company expects total revenues for fiscal 2009 to range from $175 to $200 million.
  • The company expects total manufacturing revenues to range from $113 to $125 million. The expected manufacturing revenues for RISPERDAL CONSTA range from $106 to $114 million and are based on a purchase forecast from Janssen. The expected manufacturing revenues for VIVITROL range from $7 to $11 million and are based on the latest expectations with respect to manufacturing volumes in fiscal 2009. End-market gross sales of VIVITROL are expected to range from $25 to $35 million. The company is continuing to work toward its goal of reaching break-even on the product in collaboration with Cephalon, Inc (Cephalon). Both Janssen and Cephalon have the right to change the timing and amount of their purchases. Alkermes' revenue estimates are also dependent upon its ability to manufacture sufficient quantities of RISPERDAL CONSTA and VIVITROL to meet its partners' estimates.
  • The company expects royalty revenues from RISPERDAL CONSTA to range from $32 to $35 million and no significant changes in exchange rates. This expectation assumes continued sales growth in the U.S. and around the world. Alkermes relies on sales projections received from Janssen to determine royalty revenue expectations and such projections are subject to change. RISPERDAL CONSTA sales are dependent on Janssen.
  • The company expects research and development revenues to range from $20 to $25 million. Research and development revenues, which are received from Alkermes' corporate partners, can fluctuate as these partners may terminate or change the scope and timing of the programs at any time.
  • The company expects net collaborative profit to range from $10 to $15 million. This expectation reflects the recognition of milestone revenue related to the license provided by the company to Cephalon and sharing the net profit or loss earned on the product. Spending on the VIVITROL program is approved jointly by Alkermes and Cephalon and is subject to change at any time.
  • Cost of Goods Manufactured: The company expects total cost of goods manufactured to range from $40 to $50 million. The expected cost of goods manufactured related to RISPERDAL CONSTA range from $35 to $40 million. The expected cost of goods manufactured related to VIVITROL range from $5 to $10 million. These costs are estimated based on projected orders from Janssen and Cephalon and are based on the company's historical manufacturing yields. Margins on RISPERDAL CONSTA are dependent on many factors and may fluctuate. Orders from Janssen and Cephalon are subject to change at any time.
  • Research and Development Expenses: The company expects R&D expenses to range from $95 to $100 million. These expectations reflect the company's continuing efforts to advance its product candidates toward commercialization. There are no expenses related to the development of AIR Insulin following the termination of the program by Lilly.
  • Selling, General and Administrative Expenses: The company expects SG&A expenses to range from $55 to $60 million.
  • Operating Loss: The company expects operating loss to range from $10 to $15 million.
  • Net Interest and Income Taxes: The company expects interest income will offset interest expense and that the company will not pay income taxes due to the generation of a taxable loss in fiscal 2009.
  • Net Loss: The company expects net loss to range from $10 to $15 million, or a basic and diluted loss per share of approximately $0.11 to $0.16 per share. The basic loss per share is based on an estimated 95 million weighted average shares outstanding for fiscal 2009.
  • Cash Flow from Operations: The company expects positive cash flow from operations to range from $1 to $5 million in fiscal 2009.
  • SFAS 123R: The company has included share-based compensation expense in the expense expectations provided. The company expects to recognize this expense within cost of goods manufactured, R&D expenses and SG&A expenses in the approximate ratio of 10%, 35% and 55%, respectively. Based on the company's expectation with respect to fiscal 2009 stock grants and the estimates used to value such grants, the company expects share-based compensation expense to be in the range of $15 to $20 million or $0.15 to $0.21 per share for fiscal 2009.

Conference Call

Alkermes will host a conference call at 4:30 p.m. EDT on Thursday, May 22, 2008 to discuss these financial results and provide an update on the company. The conference call may be accessed by dialing 1-866-847-7861 for domestic callers and 1-703-639-1428 for international callers. The conference call ID number is 1237335. In addition, a replay of the conference call will be available from 7:30 p.m. EDT on Thursday, May 22, 2008 through 5:00 p.m. EDT on Wednesday, May 28, 2008, and may be accessed by visiting Alkermes' website or by dialing 1-888-266-2081 for domestic callers and 1-703-925-2533 for international callers. The replay access code is 1237335. Alkermes is also providing a podcast MP3 file available for download on the Alkermes website, which will be available shortly following the conference call and will be available until May 28, 2008.

About Alkermes

Alkermes, Inc., a biotechnology company committed to developing innovative medicines to improve patients' lives, manufactures RISPERDAL(R) CONSTA(R) for schizophrenia and developed and manufactures VIVITROL(R) for alcohol dependence. Alkermes' robust pipeline includes extended-release injectable, pulmonary and oral products for the treatment of prevalent, chronic diseases, such as central nervous system disorders, addiction and diabetes. Headquartered in Cambridge, Massachusetts, Alkermes has research and manufacturing facilities in Massachusetts and Ohio.

Certain statements set forth above may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to: statements concerning future business and operating results; the successful manufacture and commercialization of VIVITROL and RISPERDAL CONSTA; continued revenue growth from RISPERDAL CONSTA; and the successful continuation of development activities for the company's programs. Although the company believes that such statements are based on reasonable assumptions within the bounds of its knowledge of its business and operations, the forward-looking statements are neither promises nor guarantees and the company's business is subject to significant risk and uncertainties and there can be no assurance that its actual results will not differ materially from its expectations. These risks and uncertainties include, among others: whether the company will achieve the financial expectations provided; whether the company can continue to manufacture RISPERDAL CONSTA and VIVITROL on a commercial scale, economically or in sufficient quantities to supply the market; whether VIVITROL will be commercialized successfully by Alkermes and its partner, Cephalon; whether RISPERDAL CONSTA will continue to be commercialized successfully by its partner Janssen; whether the company is able to successfully and efficiently scale up and manufacture its product candidates; whether advancement of the company's partnered product candidates will be delayed due to actions or decisions by its partners with regard to development and regulatory strategy, timing and funding which are out of its control; the outcome of clinical and preclinical work the company and its partners are pursuing; decisions by the FDA or foreign regulatory authorities regarding the company's product candidates; potential changes in cost, scope and duration of clinical trials; and whether RISPERDAL CONSTA, VIVITROL and the company's product candidates, in commercial use, may have unintended side effects, adverse reactions or incidents of misuse that could cause the FDA or other health authorities to require post-approval studies or require removal of its products from the market. For further information with respect to factors that could cause the company's actual results to differ materially from expectations, reference is made to the reports the company filed with the Securities and Exchange Commission under the Securities Exchange Act of 1934, as amended. The forward-looking statements made in this release are made only as of the date hereof and the company disclaims any intention or responsibility for updating predictions or financial expectations contained in this release.

(tables follow)

VIVITROL(R) is a registered trademark of Cephalon, Inc.; RISPERDAL(R) CONSTA(R) is a registered trademark of Janssen-Cilag group of companies.

Alkermes, Inc. and Subsidiaries
Selected Financial Information

                                          Year         Year
                                          Ended       Ended
Consolidated Statements of Income       March 31,   March 31,
(In thousands, except per share data)     2008         2007
---------------------------------------------------------------
Revenues:
  Manufacturing revenues                  $101,700     $105,416
  Royalty revenues                          29,457       23,151
  Research and development revenue
   under collaborative arrangements         89,510       74,483
  Net collaborative profit                  20,050       36,915
---------------------------------------------------------------
    Total Revenues                         240,717      239,965
---------------------------------------------------------------
Expenses:
  Cost of goods manufactured                40,677       45,209
  Research and development                 125,268      117,315
  Selling, general and administrative       59,508       66,399
  Impairment of long-lived assets           11,630            -
  Restructuring                              6,423            -
---------------------------------------------------------------
    Total Expenses                         243,506      228,923
---------------------------------------------------------------
Operating (Loss) Income                    (2,789)       11,042
---------------------------------------------------------------
Other Income (Expense):
  Gain on sale of investment in
   Reliant Pharmaceuticals, Inc.           174,631            -
  Interest income                           17,834       17,707
  Interest expense                        (16,370)     (17,725)
  Other expense                              (476)        (481)
---------------------------------------------------------------
    Total Other Income (Expense)           175,619        (499)
---------------------------------------------------------------
Income Before Income Taxes                 172,830       10,543
---------------------------------------------------------------
Income Taxes                               (5,851)      (1,098)
---------------------------------------------------------------
Net Income                                $166,979       $9,445
---------------------------------------------------------------

Earnings per Common Share:
  Basic                                      $1.66        $0.10
---------------------------------------------------------------
  Diluted                                    $1.62        $0.09
---------------------------------------------------------------

Weighted Average Number of Common Shares Outstanding (GAAP and
 Pro Forma):
  Basic                                    100,742       99,242
---------------------------------------------------------------
  Diluted                                  102,923      103,351
---------------------------------------------------------------

Pro Forma Reconciliation:
Net Income - GAAP                         $166,979       $9,445
  Share-based compensation expense          19,445       27,687
  Impairment of long-lived assets           11,630            -
  Restructuring                              6,423            -
  Gain on sale of investment in
   Reliant Pharmaceuticals, Inc. (net
   of income taxes)                      (171,294)            -
  Net (increase) decrease in the fair
   value of warrants                       (1,423)          743
---------------------------------------------------------------
Net Income - Pro Forma                     $31,760      $37,875
---------------------------------------------------------------

Pro Forma Earnings per Common Share:
  Basic                                      $0.32        $0.38
---------------------------------------------------------------
  Diluted                                    $0.31        $0.37
---------------------------------------------------------------

Condensed Consolidated Balance Sheets              March    March
                                                     31,      31,
(In thousands)                                      2008     2007
-------------------------------------------------------------------
Cash, cash equivalents and total investments      $460,361 $357,466(1)
Receivables                                         47,249   56,049
Prepaid expenses and other current assets            5,720    7,054
Inventory                                           18,884   18,190
Property, plant and equipment, net                 112,539  123,595
Other assets                                        11,558    6,267(1)
-------------------------------------------------------------------
Total Assets                                      $656,311 $568,621
-------------------------------------------------------------------
Unearned milestone revenue - current portion        $5,927  $11,450
Other current liabilities                           36,093   50,610
Non-recourse RISPERDAL CONSTA secured 7% notes     160,324  156,851
Unearned milestone revenue - long-term portion     111,730  117,300
Deferred revenue - long-term portion                27,837   22,153
Other long-term liabilities                          9,086    6,796
Total shareholders' equity                         305,314  203,461
-------------------------------------------------------------------
Total Liabilities and Shareholders' Equity        $656,311 $568,621
-------------------------------------------------------------------



Note:
(1) Long-term investments of $0.7 million that were classified as
 other assets in fiscal 2007, were reclassified to cash, cash
 equivalents and total investments to conform to the fiscal 2008
 presentation.

This selected financial information should be read in conjunction with
 the consolidated financial statements and notes thereto included in
 the company's Annual Report on Form 10-K for the year ended March 31,
 2008, which the company intends to file by May 30, 2008.

Alkermes, Inc. and Subsidiaries
Quarterly Financial Data Fiscal Year 2008


                                          Three Months Ended
                                --------------------------------------
(Unaudited)                              September December
                                June 30,    30,       31,    March 31,
(In thousands, except per share
 data)                             2007      2007      2007      2008
----------------------------------------------------------------------

Revenues:
   Manufacturing revenues       $31,517   $24,137   $14,275   $31,771
   Royalty revenues               6,982     7,348     7,384     7,743
   Research and development
    revenue under collaborative
    arrangements                 23,450    21,206    23,985    20,869
   Net collaborative profit       6,989     5,909     5,127     2,025
----------------------------------------------------------------------
         Total Revenues          68,938    58,600    50,771    62,408
----------------------------------------------------------------------

Expenses:
   Cost of goods manufactured    10,145     9,218     7,499    13,815
   Research and development      32,619    28,317    30,395    33,937
   Selling, general and
    administrative               15,400    14,487    15,249    14,372
   Impairment of long-lived
    assets                            -         -         -    11,630
   Restructuring                      -         -         -     6,423
----------------------------------------------------------------------
         Total Expenses          58,164    52,022    53,143    80,177
----------------------------------------------------------------------

Operating Income (Loss)          10,774     6,578    (2,372)  (17,769)
----------------------------------------------------------------------

Other Income (Expense):
   Gain on sale of investment
    in Reliant Pharmaceuticals,
    Inc.                              -         -   174,631         -
   Interest income                4,402     4,246     4,292     4,894
   Interest expense              (4,073)   (4,077)   (4,088)   (4,132)
   Other income (expense), net       26     1,151      (393)   (1,260)
----------------------------------------------------------------------
         Total Other Income
          (Expense)                 355     1,320   174,442      (498)
----------------------------------------------------------------------

Income (Loss) before Income
 Taxes                           11,129     7,898   172,070   (18,267)
----------------------------------------------------------------------
Income taxes                     (2,382)     (200)   (3,189)      (80)
----------------------------------------------------------------------
Net Income (Loss)                $8,747    $7,698  $168,881  ($18,347)
----------------------------------------------------------------------

Earnings (Loss) per common
 share:
   Basic                          $0.09     $0.08     $1.66    ($0.19)
----------------------------------------------------------------------
   Diluted                        $0.08     $0.07     $1.63    ($0.19)
----------------------------------------------------------------------

Weighted Average Number of
 Common Shares Outstanding:
   Basic                        101,324   101,595   101,703    97,919
----------------------------------------------------------------------
   Diluted                      104,191   104,315   103,914    97,919
----------------------------------------------------------------------



                                                  Year Ended
                                                --------------
(Unaudited)                                       March 31,
(In thousands, except per share data)                    2008
--------------------------------------------------------------

Revenues:
    Manufacturing revenues                           $101,700
    Royalty revenues                                   29,457
    Research and development revenue under
     collaborative arrangements                        89,510
    Net collaborative profit                           20,050
--------------------------------------------------------------
          Total Revenues                              240,717
--------------------------------------------------------------

Expenses:
    Cost of goods manufactured                         40,677
    Research and development                          125,268
    Selling, general and administrative                59,508
    Impairment of long-lived assets                    11,630
    Restructuring                                       6,423
--------------------------------------------------------------
          Total Expenses                              243,506
--------------------------------------------------------------

Operating Income (Loss)                                (2,789)
--------------------------------------------------------------

Other Income (Expense):
    Gain on sale of investment in Reliant
     Pharmaceuticals, Inc.                            174,631
    Interest income                                    17,834
    Interest expense                                  (16,370)
    Other income (expense), net                          (476)
--------------------------------------------------------------
          Total Other Income (Expense)                175,619
--------------------------------------------------------------

Income (Loss) before Income Taxes                     172,830
--------------------------------------------------------------
Income taxes                                           (5,851)
--------------------------------------------------------------
Net Income (Loss)                                    $166,979
--------------------------------------------------------------

Earnings (Loss) per common share:
    Basic                                               $1.66
--------------------------------------------------------------
    Diluted                                             $1.62
--------------------------------------------------------------

Weighted Average Number of Common Shares
 Outstanding:
    Basic                                             100,742
--------------------------------------------------------------
    Diluted                                           102,923
--------------------------------------------------------------


This quarterly financial data should be read in conjunction with the
 consolidated financial statements and notes thereto included in the
 company's Annual Report on Form 10-K for the year ended March 31,
 2008, which the company intends to file by May 30, 2008.

Alkermes, Inc. and Subsidiaries
VIVITROL(R) Selected Financial        Three     Fiscal
 Information                           Months     Year
                                       Ended     Ended
 (Unaudited, in thousands)           March 31, March 31,  Cumulative
                                       2008      2008    Collaboration
                                     --------- --------- -------------
 VIVITROL Income Statement
                         Alkermes'
                          expenses      $3,495  $17,588       $68,809
                         Cephalon's
                          net
                          product
                          losses         2,184   37,844       105,968

                                     ---------------------------------
 VIVITROL net losses                    $5,679  $55,432      $174,777
                                     ---------------------------------


 Flow of funds
                         Alkermes
                          paid
                          Cephalon:
                          net
                          product
                          losses up
                          to the
                          $124.6
                          million
                          net loss
                          cap (1)           $0  ($5,223)     ($73,347)
                         Cephalon
                          paid
                          Alkermes:
                          Alkermes'
                          expenses
                          in excess
                          of the net
                          loss cap
                          through
                          December
                          31, 2007           0   14,060        14,060
                         Cephalon
                          paid
                          Alkermes:
                          Alkermes'
                          expenses
                          in excess
                          of its
                          share of
                          net
                          product
                          losses
                          after
                          December
                          31, 2007         713      713           713

                                     ---------------------------------
 Net flow of funds from (to)
  Cephalon (3)                            $713   $9,550      ($58,574)
                                     ---------------------------------


 Net Collaborative Profit
                         Milestone
                          revenue
                          recognized
                          to offset
                          Alkermes'
                          non-shared
                          expenses
                          and
                          expenses
                          up to the
                          net loss
                          cap (1)           $0   $5,256      $144,493
                         Milestone
                          revenue
                          recognized
                          with
                          respect to
                          the
                          license
                          (2)            1,312    5,244        10,331
                         Net flow of
                          funds from
                          (to)
                          Cephalon
                          (3)              713    9,550       (58,574)

                                     ---------------------------------
 Net collaborative profit               $2,025  $20,050       $96,250
                                     =================================


                    Notes
 ------------------------
                      (1)Expenses incurred on behalf of the
                          collaboration by Alkermes, Inc. ("Alkermes")
                          and net losses incurred on behalf of the
                          collaboration by Cephalon, Inc. ("Cephalon")
                          contribute to the cumulative net product
                          losses incurred on VIVITROL. Alkermes was
                          responsible for the first $124.6 million of
                          these cumulative net product losses (the
                          "net loss cap"). Alkermes recognized
                          milestone revenue to offset the net product
                          losses incurred up to the net loss cap. The
                          collaboration reached the net loss cap in
                          April 2007, at which point the recognition
                          of milestone revenue related to this
                          accounting unit stopped. In addition, in
                          prior periods, Alkermes recognized $19.9
                          million of milestone revenue to offset
                          expenses it incurred for which it was solely
                          responsible, related to the successful FDA
                          approval of VIVITROL and the successful
                          completion of the first VIVITROL
                          manufacturing line. These $19.9 million of
                          expenses, did not contribute to the
                          cumulative net product losses.

                      (2)Milestone revenue related to the license
                          commenced upon approval of VIVITROL, by the
                          FDA, on April 13, 2006 and is being
                          recognized on a straight line basis over 10
                          years, at the rate of approximately $1.3
                          million per quarter.

                      (3)Alkermes was responsible for net losses up to
                          the net loss cap and reimbursed Cephalon for
                          their net losses during this period. Once
                          the net loss cap was reached in April 2007,
                          Cephalon reimbursed Alkermes for its
                          VIVITROL expenses through December 31, 2007.
                          Effective January 1, 2008, the two companies
                          share any net profits or losses on the
                          product.

                         Through March 31, 2008, Alkermes has
                          recognized $157.0 million of milestone
                          revenue out of the $274.6 million received
                          from Cephalon. In addition to (1) and (2)
                          above, this recognition includes $2.1
                          million of milestone revenue related to a
                          10% mark-up on manufacturing revenue, which
                          is reported by Alkermes within manufacturing
                          revenues in the consolidated statements of
                          income and comprehensive income.

CONTACT: Alkermes, Inc.
James Frates, 617-494-0171
Chief Financial Officer
or
Alkermes, Inc.
Rebecca Peterson, 617-583-6378
Vice President, Corporate Communications

SOURCE: Alkermes